Spravato (Esketamine)

Spravato Information:

Buy Spravato

Spravato (Esketamine) is used for the management of major depression. It is typically used along with other medications to manage treatment-resistant depression and severe depression with suicidal ideations. Its active ingredient, esketamine, is derived from ketamine and belongs to a class of drugs called NMDA (N-methyl-D-aspartate) receptor antagonists. Unlike antidepressants that affect serotonin, dopamine, or norepinephrine, esketamine modulates glutamate, the brain's primary excitatory neurotransmitter. This modulation helps restore synaptic connections in the brain, resulting in rapid mood improvements, often within hours or days, making it practical for individuals who haven't responded to other treatments.

Generic Spravato from Canada

Canada Drugs Online proudly serves you the brand Spravato (currently unavailable), manufactured by Janssen from Canada. The generic Spravato is currently not available. Please call us toll-free at 1-877-900-3784 for details.

CanadaDrugsOnline.com also carries other Antidepressant drugs such as Celexa and Prozac.

Spravato Side Effects:

Common mild side effects of this medication include dizziness, nausea, sedation, spinning sensation (vertigo), numbness, anxiety, lethargy, and vomiting. Contact your doctor if these mild side effects persist or worsen.

Possible serious side effects of this medication include vision loss, blurred vision, eye pain or swelling, fast, irregular, or pounding heartbeats, fainting, severe headache, confusion, slurred speech, arm or leg weakness, worsening depression, suicidal ideations, memory issues, painful or increased urination, chest pain, seizure, severe body itching, rash, swelling of your face, lips, tongue, or throat, difficulty breathing, and extreme dizziness. Stop using this medication and seek immediate medical attention if you observe these severe side effects. Additionally, inform your doctor about any other side effects not listed here.

Clinical trials, including the TRANSFORM-2 and ASPIRE I/II studies, found that esketamine significantly reduced depression symptoms compared to a placebo in adults with treatment-resistant depression (TRD), providing rapid symptom relief within days. Patients receiving esketamine were more likely to achieve remission and remain relapse-free than those using other TRD treatments, such as quetiapine, over eight weeks and continuing through 32 weeks. While it is generally well tolerated in most individuals, its complete safety profile is still being explored due to the potential risks of sedation and dissociation. Like other antidepressants, it also has the potential to cause worsening depression and suicidal thoughts, especially in children and young adults. Hence, it is best administered under healthcare supervision, typically in a clinical setting.

Spravato Directions:

This medication is administered intranasally through a nasal spray device, which should not be primed before use. Your doctor will determine the appropriate dose of this medication for you. Do not eat for at least 2 hr before administration. Spravato is best administered under your doctor's supervision at a certified healthcare facility due to potential side effects and safety monitoring requirements. Store this medication at room temperature and keep it away from children and pets.

Spravato Precautions:

Before using this medication, make sure you inform your doctor about any medical conditions you have had or currently have especially the following:
• Allergic reaction to esketamine, other ingredients of Spravato, or any other medication;
• Bleeding disorders;
• Heart disease;
• High blood pressure;
• Kidney disease;
• Liver disease;
• Lung problems;
• Overactive thyroid gland;
• Psychosis;
• Stroke;
• Substance abuse;
• Vascular diseases such as arteriovenous malformation, aneurysm

Do not drive or do other activities that require alertness or coordination until you know how Spravato affects you, as it can cause dizziness and drowsiness. Avoid smoking and the use of alcohol while taking this medication. This medication should not be used during pregnancy or while breastfeeding. It should also not be used in individuals younger than 18 years. Some medicines may interact with esketamine, affecting how it works in the body. Such medications include:
• Buprenorphine;
• Fentanyl;
• Methohexital;
• Metoclopramide;
• Olopatadine;
• Zuranolone

Therefore, make sure you inform your doctor about all the medications, including herbal medicines and supplements you are taking, before using Spravato to prevent drug interactions.