Cotellic (Cobimetinib Fumarate)

Cotellic Information:

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Cotellic (Cobimetinib Fumarate) is used in the treatment of a specific type of skin cancer called melanoma. It is specifically approved for use in combination with another drug called vemurafenib to treat an advanced/severe form of melanoma that has a specific genetic mutation known as BRAF V600E or V600K. This mutation promotes the uncontrolled growth of cancer cells. Cotellic is also used to treat histiocytic neoplasms, which are a group of rare diseases where certain white blood cells called histiocytes grow and accumulate abnormally in the body. The active ingredient in Cotellic is cobimetinib fumarate, which belongs to a group of medications called protein kinase inhibitors. Cotellic (cobimetinib) works by blocking a protein called MEK, which is involved in the growth and division of cancer cells. By inhibiting MEK, Cotellic helps to slow down the growth of cancer cells, prevent them from multiplying and spreading, and shrink tumors, thus improving the overall outcomes for patients with advanced melanoma and histiocytic neoplasms.

Generic Cotellic from Canada

Canada Drugs Online is proud to serve you the brand Cotellic from Canada manufactured by Hoffman - La Roche. The generic form of this medication is currently not available. Please call us toll-free at 1-877-900-3784 for details.

CanadaDrugsOnline.com also carries other Cancer Medications such as Gleevac and Tarceva.

CanadaDrugsOnline.com supplies only genuine Cotellic from Canada shipped using the Canadian packaging. This Cotellic is manufactured by Genetech Inc. (a member of Roche Group), the worldwide manufacturer of Cotellic. This offer is neither endorsed nor authorized by Genetech Inc. (the United States and Canadian distributor of Cotellic). CanadaDrugsOnline.com has no affiliation whatsoever with Genetech Inc.

Cotellic Side Effects:

Common mild side effects of this medication may include abdominal pain, chills, diarrhea, dizziness, dry mouth, fever, mouth sores, muscle aches, nausea, red, swollen, or itchy eyes, sore throat, stuffy or runny nose, and vomiting. If any of these common mild side effects persist or worsen, it is important to contact your doctor immediately.

Possible serious side effects of this medication can include high blood pressure, skin sores and lumps, warts, easy bleeding or bruising, unusual vaginal bleeding, black or bloody stools, vomit that contains blood or looks like coffee grounds, bloody urine, muscle pain, tenderness or weakness, abnormal change in the amount of urine, shortness of breath, swelling ankles and feet, unusual tiredness, unusual or sudden weight gain, blurred vision, vision loss, seeing halos, persistent nausea and vomiting, loss of appetite, abdominal pain, yellowing of the eyes, dark urine, severe headache, weakness on one side of the body, sudden vision changes, trouble speaking, seizures, confusion, severe body itching and rash, swelling of your face, lips, tongue, or throat, difficulty breathing, and extreme dizziness. If any of these serious side effects occur, it is important to stop the medication immediately and seek immediate medical attention. Additionally, inform your doctor about any other side effects that you may have noticed, even if they are not listed here.

Cotellic Directions:

Cotellic is administered orally in the form of tablets according to your doctor's prescription. The appropriate dose of this medication will be determined by your doctor, taking into account factors such as your pre-existing medical condition and other relevant considerations. For more detailed information on dosage and instructions for use, please refer to the leaflet included in the packaging. It is important not to miss any doses of Cotellic and to avoid exceeding the prescribed dose. Store Cotellic at room temperature, protect it from light and moisture, and keep it out of the reach of children.

Clinical studies have demonstrated the safety and efficacy of Cotellic in improving outcomes for patients with advanced melanoma when used in combination with vemurafenib. The elimination half-life of the drug can range from 20 to 70 hours, depending on individual factors.

Cotellic Precautions:

Before using this medication, it is important to inform your doctor about any previous or current medical conditions you may have, especially the following:
• Allergic reaction to Cobimetinib, other ingredients of Cotellic, or any other medication;
• Blood cell disorders such as anemia;
• Bleeding disorders;
• Eye problems such as glaucoma;
• Heart problems;
• High blood pressure;
• Kidney disease;
• Liver disease;
• Muscle problems such as rhabdomyosarcoma.

It is crucial to avoid driving or operating heavy machinery while taking this medication until you are aware of its effects on you, as it may cause dizziness and blurry vision that can impair your ability to safely perform these activities. Smoking and consuming alcohol or alcoholic beverages should be refrained from while using this medication, as they can potentially contribute to the development of side effects. Minimizing sun exposure is important while taking this medication, as it can make your skin more sensitive to sunlight and increase the risk of sunburn. When outdoors during the day, wear protective clothing and sunglasses.

Do not use this medication during pregnancy or while breastfeeding. It is recommended to use effective forms of contraception while taking this medication to prevent pregnancy. Inform your doctor immediately if you become pregnant while taking this medication. Cotellic is not recommended for use in individuals younger than 18 years. Use caution when administering this medication to elderly individuals, as they are at a higher risk of developing side effects.

Several medications and substances can interact with Cotellic and affect its action in the body. Some of these include:
• Antibiotics such as clarithromycin and erythromycin;
• Antifungal medications such as itraconazole and fluconazole;
• Antiarrhythmics such as amiodarone;
• Blood pressure medications such as diltiazem and verapamil;
• Grapefruit;
• Other cancer drugs like imatinib.

Therefore, before using Cotellic, it is important to inform your doctor about any other medications you are currently taking, including herbal medications and supplements, to determine if it is safe to use them along with Cotellic.