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Inspra (Eplerenone)

Type
Product
Manufacturer
Country
Dosage
Qty
Price(USD)
Type: drug type
Product: Inspra 
Manufacturer: Pfizer
Country: United Kingdom
Dosage: 25 mg
Qty: 28
USD $149.99
Type: drug type
Product: Inspra 
Manufacturer: Upjohn
Country: Canada
Dosage: 25 mg
Qty: 30
USD $147.99
Type: drug type
Product: Inspra 
Manufacturer: Pfizer
Country: United Kingdom
Dosage: 25 mg
Qty: 84
USD $399.99
Type: drug type
Product: Inspra 
Manufacturer: Upjohn
Country: Canada
Dosage: 25 mg
Qty: 90
USD $397.99
Type: drug type
Product: Inspra 
Manufacturer: Pfizer
Country: United Kingdom
Dosage: 50 mg
Qty: 28
USD $159.99
Type: drug type
Product: Inspra 
Manufacturer: Upjohn
Country: Canada
Dosage: 50 mg
Qty: 30
USD $151.99
Type: drug type
Product: Inspra 
Manufacturer: Pfizer
Country: United Kingdom
Dosage: 50 mg
Qty: 84
USD $409.99
Type: drug type
Product: Inspra 
Manufacturer: Upjohn
Country: Canada
Dosage: 50 mg
Qty: 90
USD $407.99
Type: drug type
Product: Eplerenone 
Manufacturer: Generic
Country: India
Dosage: 25 mg
Qty: 90
USD $134.99
Type: drug type
Product: Eplerenone 
Manufacturer: Generic
Country: Canada
Dosage: 25 mg
Qty: 90
USD $299.99
Type: drug type
Product: Eplerenone 
Manufacturer: Generic
Country: Canada
Dosage: 50 mg
Qty: 90
USD $329.99
Type: drug type
Product: Eplerenone 
Manufacturer: Generic
Country: India
Dosage: 50 mg
Qty: 100
USD $188.99

Inspra from Canada

Inspra Information:

Inspra contains eplerenone, a blocker of aldosterone binding at the mineralocorticoid receptor. INSPRA is indicated to improve survival of stable patients with left ventricular systolic dysfunction (ejection fraction 40%) and clinical evidence of congestive heart failure after an acute myocardial infarction.

INSPRA tablets contain 25 mg or 50 mg of eplerenone. The principal risk of INSPRA is hyperkalemia. Hyperkalemia can cause serious, sometimes fatal, arrhythmias. This risk can be minimized by patient selection, avoidance of certain concomitant treatments, and monitoring. For patient selection and avoidance of certain concomitant medications.

INDICATIONS AND USAGE Congestive Heart Failure Post-Myocardial Infarction INSPRA is indicated to improve survival of stable patients with left ventricular systolic dysfunction (ejection fraction £40%) and clinical evidence of congestive heart failure after an acute myocardial infarction. INSPRA is indicated for the treatment of hypertension. INSPRA may be used alone or in combination with other antihypertensive agents.

Inspra Side Effects:

Inspra side effect profile coming soon: Drug-drug interaction studies were conducted with a 100 mg dose of eplerenone. Eplerenone is metabolized primarily by CYP3A4. A potent inhibitor of CYP3A4 (ketoconazole) caused increased exposure of about 5-fold while less potent CYP3A4 inhibitors (erythromycin, saquinavir, verapamil, and fluconazole) gave approximately 2- fold increases. Grapefruit juice caused only a small increase (about 25%) in exposure. The recommended dose of INSPRA is 50 mg once daily. Treatment should be initiated at 25 mg once daily and titrated to the target dose of 50 mg once daily preferably within 4 weeks as tolerated by the patient. INSPRA may be administered with or without food. Serum potassium should be measured before initiating INSPRA therapy, within the first week and at one month after the start of treatment or dose adjustment. Serum potassium should be assessed periodically thereafter. Factors such as patient characteristics and serum potassium levels may indicate that additional monitoring is appropriate. INSPRA (Eplerenone) binds to the mineralocorticoid receptor and blocks the binding of aldosterone, a component of the renin-angiotensin-aldosterone-system (RAAS). Aldosterone synthesis, which occurs primarily in the adrenal gland, is modulated by multiple factors, including angiotensin II and non-RAAS mediators such as adrenocorticotropic hormone (ACTH) and potassium. Aldosterone binds to mineralocorticoid receptors in both epithelial (e.g., kidney) and nonepithelial (e.g., heart, blood vessels, and brain) tissues and increases blood pressure through induction of sodium reabsorption and possibly other mechanisms. INSPRA (Eplerenone) has been shown to produce sustained increases in plasma renin and serum aldosterone, consistent with inhibition of the negative regulatory feedback of aldosterone on renin secretion. The resulting increased plasma renin activity and aldosterone circulating levels do not overcome the effects of INSPRA (Eplerenone).
The generic alternative is not manufactured by the company that makes the brand product.

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