Motilium (generic name: Domperidone) is a drug which is prescribed for the relief of symptoms of fullness, bloating, nausea and other stomach discomfort after eating. It is also effective in relieving heartburn and trapped wind, as well as vomiting and nausea caused by migraines, stress, food poisoning, viruses and drugs taken for the treatment of Parkinson’s disease. Feelings of bloating and fullness after eating are often caused because of the digestive system slowing and not moving food effectively. The active ingredient, domperidone, works by increasing the contractions in the stomach and bowels, thus aiding digestion and relieving feelings of discomfort. Domperidone is a dopamine antagonist, and primarily blocks dopamine receptors found in the digestive system. This in turn causes the muscles at the stomach entrance to tighten, and the exit muscles to relax. These actions speed up the process whereby food is passed through the stomach and into the intestines. The action is basically inducing the natural rhythm of the digestive system.
FDA Alert on Motilium (Domperidone): How to request Domperidone for gastrointestinal disorders
Motilium Side Effects:
As with any drug, there may be side effects from taking Motilium including headache, constipation, diarrhea, decrease in appetite, abdominal cramps, dry mouth, dizziness, heartburn, insomnia and some hormonal changes such as breast enlargement or tenderness and irregular menstrual periods. More serious side effects may include change in urination, severe dizziness and difficulty balancing, muscle cramps, changes in heartbeat and allergic reactions which may include itching, swelling of the mouth, throat and lips and difficulty breathing. If you experience any side effects you must seek medical attention immediately for safety.
You should follow the instructions of the doctor who prescribed Motilium to you. Directions and dosage information can also be found on the pack or leaflet inside the pack. Motilium comes in tablet form. You should swallow Motilium whole with a glass of water. Motilium can be taken with or without food. Motilium should be stored at room temperature away from direct sunlight and heat.
Domperidone may be associated with a small increased risk of serious ventricular arrhythmias or sudden cardiac death. A higher risk was observed in patients:
• older than 60 years of age;
• using daily doses greater than 30 mg;
• having predisposing factors for QT prolongation including concomitant use of QT-prolonging drugs or CYP 3A4 inhibitors.
• Domperidone is now contraindicated in patients:
• with prolongation of cardiac conduction intervals, particularly QT;
• with significant electrolyte disturbances;
• with cardiac disease (such as congestive heart failure);
• with moderate or severe liver impairment;
• receiving QT-prolonging drugs and potent CYP3A4 inhibitors.
Domperidone should be used at the lowest effective dose to a maximum recommended daily dose of 30 mg and for the shortest possible duration.
If you are allergic to any of the ingredients of Motilium, you should avoid taking it and inform your doctor. You must consult your doctor if you have any pre-existing medical conditions including pituitary gland diseases (brain tumor), stomach or duodenal ulcer, kidney or liver disease or disorders, blocked gut (from conditions such a fecal impaction), perforated gut, any other bowel conditions, hernia or regular stomach cramps that occur for more than 14 days. You must consult your doctor if you are taking any other medications as they may interact with Motilium, including antifungal medication, antibiotics, MAO inhibitors, HIV/AIDs medication, antidepressants or any other medication for bowel and digestive disorders. It is important that you inform your doctor if you are pregnant, planning to conceive or breastfeeding as Motilium may cause harm to unborn and new born babies, and can pass to babies through breast milk.
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