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Actonel
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Clinical pharmacology of Actonel

Mechanism of Action
Actonel has a similarity for hydroxyapatite crystals in bone and acts as an antiresorptive agent. Actonel inhibits osteoclasts at the level of cellular. The osteoclasts adhere normally to the bone surface, but show evidence of reduced active resorption. Histomorphometry in rats, dogs, and minipigs showed that the treatment of Actonel reduces bone turnover and bone resorption at remodeling sites.
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