Directions
One should take mesalamine exactly as directed by the doctor. If one does not understand these directions, please ask your pharmacist or doctor to explain. Take each dose with a glass of water. Mesalamine is fine if taken with or without food. They are specially formulated to release the medication after they have passed through your stomach. Notify your doctor if you repeatedly find undissolved tablets in your stool. Try and empty your bowel just before using a rectal form of mesalamine. Insert the suppositories rectally. Remove the foil wrapper and insert a suppository into the rectum, pointed end first. One should avoid excessive handling of the suppository, because it is designed to melt at body temperature. Retain the suppository for one to three hours, or longer, if possible to get the maximum benefit from this medication.Shake the rectal suspension, remove the protective cap from the applicator tip, hold the bottle at the neck, gently insert the tip into the rectum, pointing toward the belly button (umbilicus) and then squeeze the bottle steadily to discharge most of the medication. One should retain the suspension overnight if possible to get the maximum benefit from this medication. Use caution when applying the suppositories or rectal suspension. These products may stain clothing, flooring, painted surfaces, vinyl, enamel, marble, granite, and other surfaces. The rectal suspension may darken slightly in color. Throw away any bottles that contain very dark brown liquid. Please store mesalamine at room temperature, away from moisture and heat.

Cautions
Use caution when applying the suppositories or rectal suspension. These products may cause stain clothing, flooring, painted surfaces, vinyl, enamel, marble, granite, and other surfaces. There are no restrictions on foods, beverages, or activities during therapy with mesalamine unless your doctor directs otherwise.